Molecular population genetics of sequence length diversity in the Adh region of Drosophila pseudoobscura.

摘要: Positive and negative selection on indel variation may explain the correlation between intron length recombination levels in natural populations of Drosophila. A nucleotide sequence analysis 3.5 kilobase alcohol dehydrogenase (Adh) region from 139 Drosophila pseudoobscura strains one D. miranda strain was used to determine whether positive or acts a gene that experiences high recombination. total 30 deletion 36 insertion polymorphisms were segregating within no indels fixed its two sibling species persimilis. The ratio Tajima's D theoretical minimum value (D m i n ) proposed as metric assess heterogeneity among loci when number sites differs loci. magnitude D/D found increase rate population expansion increases, allowing which have an excess rare variants due versus purifying selection. appear had modest increases size accounting for some observed variants. rejected neutral model polymorphisms. Linkage disequilibrium pairs greater than nucleotides. These results suggest removes sequences, but not Genome rearrangement size-dependent evolution are mechanisms limit runaway expansion.