Prognostic value of low CDX2 expression in colorectal cancers with a high stromal content - a short report.

摘要: Lack of expression the intestinal transcription factor CDX2 in colorectal cancer (CRC) identifies patients with a poor prognosis. This biomarker has previously been suggested to be prognostic CRCs high stromal content based on mRNA data. We investigated value microsatellite stable CRC stratified by using microscopy-based techniques. The study included cohort 236 stage I-IV CRC. assessed microscopy tumour-stroma ratio (TSR) and immunohistochemical intensity. found that stroma-high group had worse prognosis compared those stroma-low [disease-free survival multivariate analysis (DFSmultivariate) HR 1.52 (95% CI 1.05–2.21)]. In our cohort, low (14.6%) showed for DFSmultivariate [HR 1.93 1.16–3.23)]. Interestingly, when stratifying TSR, no difference was observed related tumours. However, within [DFSmultivariate 3.02 1.49–6.13)]. p interaction between TSR status borderline significant DFS (p = 0.071). present confirms outcome Low tumours identified particularly did not reveal clear associated survival. method, solely microscopy, who have risk relapse outcome, may benefit from targeted therapy.