N-GLUCOSIDE FORMATION AS A DETOXIFICATION MECHANISM IN MAMMALS
作者： J. J. Baldwin , R. E. Rhodes , D. E. Duggan , B. H. Arison
DOI:
关键词: Xanthine oxidase inhibitor 、 Detoxification 、 Biochemistry 、 Hydrolysis 、 Stereochemistry 、 Absorption (pharmacology) 、 Purine nucleoside phosphorylase 、 Sulfatase 、 Chemistry 、 Conjugate 、 Glucoside
摘要: After intravenous dosage in dogs, the major portion of xanthine oxidase inhibitor, 3-(4-pyrimidinyl)-5-(4-pynidyl)-1,2,4-triazole, is excreted bile as a polar conjugate refractory to µ-glucuronidase, sulfatase, µ-glycosidase and nucleoside phosphorylase. High resolution mass spectrometry. nuclear magnetic resonance, absorption fluorescence spectra, identification chemical hydrolysis produets recrystallized have established its structure N-(1)-µ-D-glucopyranoside. The same sigificant component renal biliary elimination rat monkey well. These constitute first reported instance N-glucosylation detoxification mechanism mammals.
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