Species differences in absorption, metabolism and excretion of pranoprofen, a 2-arylpropionic acid derivative, in experimental animals.

摘要: Absorption, metabolism and excretion of 2-(5H-[1]benzopyrano-[2,3-b]pyridin-7-yl)propionic acid (pranoprofen), an anti-inflammatory drug, were investigated in mice, rats, guinea pigs rabbits using 14C-labeled compound ( [14C]pranoprofen) at a dose 5 mg/kg. After the oral administration [14C]pranoprofen radioactivity was rapidly almost completely absorbed from digestive organs animals tested. The blood reached maximum 30--60 min after all species tested, biological half-lives 4.1 h 2.6 pigs, 1.3 mice 0.9 rabbits, respectively. When orally administered, urinary fecal excretions within 3 d 81.1% 18.7% 51.5% 39.4% 81.8% 9.0% 93.2% 3.6% A major metabolite pranoprofen its acyl glucuronide rabbits. However, it shown that glucosidation is also predominant metabolic pathway mice.