Metabolic fate of indeloxazine hydrochloride: α-glucoside formation in rats
作者： H. Kamimura , R. Kawai , H. Kudo
DOI: 10.3109/00498258809041650
关键词: Oral administration 、 Chemistry 、 Hydrochloride 、 Metabolism 、 Indeloxazine 、 Organic chemistry 、 Conjugate 、 Glucoside 、 Conjugated system 、 Hydrolysis
摘要: 1. After oral administration of indeloxazine hydrochloride ((±)-2-[(inden-7-yloxy)methyl]morpholine hydrochloride) to rats, two conjugates, which were labile α-glucosidase hydrolysis but refractory β-glucosidase, isolated from the urine.2. Mass spectral and n.m.r. analyses confirmed that these conjugates α-D-glucopyranosides M-2 (trans-4-(2-morpholinylmethoxy)-1,2-indandiol) M-3 (trans-6-[[(1,2-dihydroxy-4-indanyl)oxy]-methyl]-3-morpholinone).3. These are probably first examples foreign compounds conjugated with glucose in α-configuration.
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