γδ T lymphocyte responses to HIV

摘要: Natural immunity may be involved in controlling viral spread hosts infected with HIV. A panel of γδ T cell receptor-positive lymphocyte clones was isolated from the peripheral blood healthy HIV− donors and tested for anti-HIV cytotoxic responses. Twelve 30 (40%) Vγ9+Vδ2+ clones, but none seven Vδ1+ displayed lytic activity against HIV-infected cells. The Vγ9+/Vδ2+ cells also lysed Daudi However, not all which targets had capacity to lyse Some were investigated potential proliferative responses One clone (ME8-7) one (ME18-2) demonstrated toward Another (VM39) proliferated response cell-free Taken together, these results provide direct evidence healthy, persons.