MHC-restricted, glycopeptide-specific T cells show specificity for both carbohydrate and peptide residues.
作者： Emil R. Unanue , Jan Kihlberg , M. Brian Deck , Petter Sjölin
DOI:
关键词: Peptide 、 Disaccharide 、 Major histocompatibility complex 、 Residue (chemistry) 、 Biochemistry 、 Moiety 、 Chemistry 、 Galactose 、 Glycopeptide 、 T cell
摘要: We examined the antigenic specificity of two T cell hybridomas elicited against disaccharide galabiose attached to fifth residue I-Ak binding peptide 52–61 lysozyme. By making changes in saccharide molecule and peptide, we conclude that outer galactose moiety is directly recognized by cells together with exposed side chains peptide. The overall spatial display this on likewise important.
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