Nebulized IFN-gamma inhibits the development of secondary allergic responses in mice.

摘要: The effects of nebulized IFN-gamma on primary and secondary IgE production development airway hyper-responsiveness (AHR) were investigated. BALB/c mice received exposure to aerosolized OVA daily for 10 days developed anti-OVA responses, immediate cutaneous reactivity OVA, altered function when assayed day 12. After challenges 30 31, these an amplified response, heightened AHR measured 37. Administration 13 days, beginning 3 prior during sensitization, resulted in a decrease IgE, increases serum IgG2a levels, normal assessed 12 after sensitization. This treatment also prevented the responses responsiveness but did not induce rise Treatment with 26 30, well established just challenge, abolished increase serum, AHR. In vitro, CD4+ T cells obtained from OVA-sensitized treated either "early" or "late" inhibited production. Delivery airways can prevent allergen sensitization even has been achieved this effect is mediated by cells.