Poly(ethylene glycol) conjugation stabilizes the secondary structure of α-helices by reducing peptide solvent accessible surface area

作者: Elham Hamed , Ting Xu , Sinan Keten

DOI: 10.1021/BM401164T

关键词: Accessible surface areaMolecular dynamicsEthylene glycolPolymer chemistryHelixProtein structurePEG ratioChemistryProtein secondary structureSolvent

摘要: … (ethylene glycol) (PEG) side-chain conjugation on the conformational behavior of an α-helix using molecular dynamics simulations in explicit solvents of … helicity and solvent accessible …

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