Modelling and Simulation of Drug Delivery Systems for the Treatment of Acute Myeloid Leukemia

摘要: Cancer, including Acute Myeloid Leukemia (AML), results from the loss of control cell cycle where cells proliferate abnormally. A complicated network reactions and cell-signaling pathways are involved in this process leukemogenesis. The actions targeting chemotherapeutic treatments to interfere with abnormal signaling equally as vivo. Herein, we attempt describe through development a dynamic model for vivo single drug, cytarabine (ARA-C), used routinely treatment AML. proposed combines on cycle, which is target pharmacokinetic pharmacodynamic aspects order provide comprehensive description drug diffusion action after administration. also takes into account patient factors such age, sex, weight height an gain insights towards optimisation individual protocols effective patient-specific leukemia-specific therapy that can minimise toxicity. This may then be means obtain insight chemotherapy procedure predictive tool response during treatment, similar what have previously demonstrated breast cancer (Dua et al. 2008; Dua et.al. 2005).