Optimal control applied to cell-cycle-specific cancer chemotherapy

摘要: We propose a mathematical model for the growth of cell-cycle-specific dose limiting bone marrow. In an attempt to determine effective methods treatment without overdestruction marrow we implement optimal control theory. design functional maximize both mass and over interval. Next show that exists this problem, then characterize our in terms solutions optimality system, which is state system coupled with adjoint system. unique suitably small time intervals. Finally, analyze using numerical techniques. This allows us suggest prevent excessive destruction based on specific weights objective functional.