Reactive oxygen species production by mitochondria.
作者： Adrian J. Lambert , Martin D. Brand
DOI: 10.1007/978-1-59745-521-3_11
关键词: Electron transport chain 、 Superoxide 、 Hydroxyl radical 、 Chemistry 、 Mitochondrion 、 Primary (chemistry) 、 Superoxide dismutase 、 Reactive oxygen species 、 Biochemistry 、 Hydrogen peroxide
摘要: Oxidative damage to cellular macromolecules is believed underlie the development of many pathological states and aging. The agents responsible for this are generally thought be reactive oxygen species, such as superoxide, hydrogen peroxide, hydroxyl radical. main source species production within most cells mitochondria. Within mitochondria primary produced which converted peroxide by action superoxide dismutase. has been localized several enzymes electron transport chain, including Complexes I III glycerol-3-phosphate dehydrogenase. In chapter current consensus view sites, rates, mechanisms, topology described. A brief overview methods measuring in isolated also presented.
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