Estradiol initially enhances but subsequently suppresses (via adrenal steroids) granule cell proliferation in the dentate gyrus of adult female rats

摘要: In the dentate gyrus of adult female meadow voles, a high dose estradiol benzoate (EB) increases (within 4 h) then decreases 48) number dividing progenitor cells (Ormerod BK, Galea LAM. 2001. Reproductive status regulates cell proliferation within vole: A possible regulatory role for estradiol. Neurosci 2:169-179). We investigated whether time-dependent EB exposure differentially influences new granule produced in rat and EB-stimulated adrenal activity mediates decrease proliferation. Ovariectomized rats received either an (10 microg 0.1 mL) or vehicle (0.1 injection 48 h (Experiment 1) before BrdU (200 mg/kg) were perfused 24 later to assess cells. Relative vehicle, increased following (p < = 0.04) but decreased 0.006) EB. Experiment 2, ovariectomized adrenalectomized females did not significantly differ between groups exposed versus prior administration, suggesting observed adrenal-intact is mediated by activity. conclude that dynamically manner previously voles suppresses influencing steroids. Investigating how neurogenesis could provide insight into mechanisms which controlled rodent hippocampus.