Intraocular Pressure Control and Long-term Visual Field Loss in the Collaborative Initial Glaucoma Treatment Study

摘要: Objective To evaluate the impact of measures intraocular pressure (IOP) control on progression visual field (VF) loss during long-term treatment for open-angle glaucoma (OAG). Design Longitudinal, randomized clinical trial. Participants We included 607 participants with newly diagnosed OAG. Methods Study were randomly assigned to initial medications or trabeculectomy, and underwent examination at 6-month intervals. Standardized testing Goldmann applanation tonometry Humphrey 24-2 full threshold VFs. Summary IOP follow-up maximum, mean, standard deviation (SD), range, proportion less than 16, 18, 20, 22 mmHg, whether all values each these 4 cutpoints. Predictive models VF outcomes based mean (MD) from testing, adjusted age, gender, race, baseline loss, treatment, time. Each summary measure was as a cumulative, time-dependent variable, its association subsequent assessed 3 9 years postrandomization. Both linear mixed models, detect shifts in MD levels, logistic elevated odds substantial worsening (≥3 dB), used. Main Outcome Measures measured tests. Results The effect differed between medicine surgery groups that addressed continuous outcome. After adjustment risk factors, group larger measures—maximum ( P = 0.0003), SD 0.0056), range Conclusions These results support considering more aggressive when undue elevation variation is observed. Financial Disclosure(s) Proprietary commercial disclosure may be found after references.