Standardizing the Measurement of Intraocular Pressure for Clinical Research: Guidelines from the Eye Care Technology Forum

摘要: Although there are many different instruments available for measuring intraocular pressure (lOP), the Goldmann tonometer is international "gold standard." The advantages of tonometry include following: technique well established, equipment widely available, safe and easy to perform, measurements fairly accurate reproducible. However, a number oflimitations as well. Perhaps major limitation that lOP secondary or surrogate endpoint glaucomatous visual loss. In addition, typically fluctuates in diurnal pattern. healthy individuals, variation ranges from 3 6 mmHg but fluctuation far greater individuals with glaucoma ocular hypertension. There limited data on accuracy tonometry. factor affecting measurement corneal thickness. ,2 thin corneas underestimates by much a~ 5 at level 20 mmHg. thick corneas, overestimates 7 30 reproducibility 2 4 Phelps Phelps3 found interob-