MicroRNA Signature in Human Normal and Tumoral Neural Stem Cells.

摘要: MicroRNAs, also called miRNAs or simply miR-, represent a unique class of non-coding RNAs that have gained exponential interest during recent years because their determinant involvement in regulating the expression several genes. Despite increasing number mature recognized human species, only limited proportion is engaged ontogeny central nervous system (CNS). play pivotal role transition normal neural stem cells (NSCs) into tumor-forming NSCs. More specifically, extensive studies identified some shared between NSCs and cancer (CSCs), namely miR-7, -124, -125, -181 miR-9, -10, -130. In context NSCs, are intercalated from embryonic stages throughout differentiation pathway order to achieve neuronal lineages. Within CSCs, under different cellular context, perform tumor suppressive oncogenic functions govern homeostasis brain tumors. This review will draw attention most characterizing dealing with neurogenesis tumoral cell offering reader insight power next generation miRNA-targeted therapies against malignances.