Control of bursting behavior in neurons by autaptic modulation.

摘要: Firing properties of biological neurons have long been recognized to be determined by extrinsic synaptic afferents that receive and intrinsic ionic mechanisms possess, however, previous researches also demonstrated firing behavior single can modulated the themselves, realized autapses. Thus in this investigation, we argued how autaptic modulations shape bursting neurons. We considered issue from following two aspects: autaptic-excitation -inhibition. Our results suggested for autaptic-excitation, under condition relatively weak stimulus, regular was more incline occur when strength weak, while spiking likely appear strong. However, larger stimulus would diminish portion bursting, but increase spiking. For autaptic-inhibition, a wide range emerges small, stronger were applied, shrinked into small region. Meanwhile, observed delays no obvious effects case subtle effect autaptic-inhibition. These showed could controlled intrinsically final may further promote understanding generation various neuronal patterns.