Risk factors for EEG seizures in neonates treated with hypothermia: A multicenter cohort study
作者： H. C. Glass , C. J. Wusthoff , R. A. Shellhaas , T. N. Tsuchida , S. L. Bonifacio
DOI: 10.1212/WNL.0000000000000282
关键词: Encephalopathy 、 Medicine 、 Cohort study 、 Status epilepticus 、 Burst suppression 、 Observational study 、 Interquartile range 、 Pediatrics 、 Hypothermia 、 Anesthesia 、 Electroencephalography
摘要: Objective: To assess the risk factors for electrographic seizures among neonates treated with therapeutic hypothermia hypoxic-ischemic encephalopathy (HIE). Methods: Three-center observational cohort study of 90 term hypothermia, monitored continuous video-EEG (cEEG) within first day life (median age at onset recording 9.5 hours, interquartile range 6.3–14.5), and continued >24 hours (total 93.3 80.1–112.8 survivors). A pediatric electroencephalographer each site reviewed cEEGs initial EEG background category. Results: total 43 (48%) had seizures, including 9 (10%) status epilepticus. Abnormal classification (excessively discontinuous, depressed undifferentiated, burst suppression, or extremely low voltage), but not clinical variables (including pH Conclusions: Electrographic are common HIE undergoing difficult to predict based on features. These results justify recommendation cEEG monitoring in hypothermia.
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