Alteration of synaptic plasticity by neonatal seizures in rat somatosensory cortex.
作者： Elena Isaeva , Dmytro Isaev , Gregory L. Holmes
DOI: 10.1016/J.EPLEPSYRES.2013.03.011
关键词:
摘要: Seizures in newborns are associated with a high risk for subsequent epilepsy and adverse neurodevelopmental consequences. Understanding the mechanisms by which neonatal seizures adversely disturb immature brain is important developing therapeutic strategies. Using convulsant agent flurothyl to mimic repetitive we show that early-life result long-term alteration maintenance phase of potentiation (LTP) layer IV II/III synapses somatosensory cortex without basal synaptic transmission, induction LTP short-term depression. Such alterations may have role functional deficits seen following seizures.
sci-hub.se 参考文章(20)
Marita Meins, Uwe Frey, Gilles Sansig, Chantal Portet, Markus Schmutz, Markus Schröder, Cordula Nitsch, Jean-Paul Laurent, Denis Monard, Andreas Lüthi, Herman van der Putten, Florence M. Botteri, Isabelle M. Mansuy, Endogenous Serine Protease Inhibitor Modulates Epileptic Activity and Hippocampal Long-Term Potentiation The Journal of Neuroscience. ,vol. 17, pp. 4688- 4699 ,(1997) , 10.1523/JNEUROSCI.17-12-04688.1997
Hannah C Glass, Karen J Hong, Elizabeth E Rogers, Rita J Jeremy, Sonia L Bonifacio, Joseph E Sullivan, A James Barkovich, Donna M Ferriero, Risk Factors for Epilepsy in Children With Neonatal Encephalopathy Pediatric Research. ,vol. 70, pp. 535- 540 ,(2011) , 10.1203/PDR.0B013E31822F24C7
Jana Velíšková, Alexandra M. Miller, Magda L. Nunes, Lucy L. Brown, Regional neural activity within the substantia nigra during peri-ictal flurothyl generalized seizure stages. Neurobiology of Disease. ,vol. 20, pp. 752- 759 ,(2005) , 10.1016/J.NBD.2005.05.007
Elena Isaeva, Dmytro Isaev, Alina Savrasova, Rustem Khazipov, Gregory L. Holmes, Recurrent neonatal seizures result in long-term increases in neuronal network excitability in the rat neocortex. European Journal of Neuroscience. ,vol. 31, pp. 1446- 1455 ,(2010) , 10.1111/J.1460-9568.2010.07179.X
Jennifer M Kwon, Ronnie Guillet, Seetha Shankaran, Abbot R Laptook, Scott A McDonald, Richard A Ehrenkranz, Jon E Tyson, T Michael O'Shea, Ronald N Goldberg, Edward F Donovan, Avroy A Fanaroff, W Kenneth Poole, Rosemary D Higgins, Michele C Walsh, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, None, Clinical Seizures in Neonatal Hypoxic-Ischemic Encephalopathy Have No Independent Impact on Neurodevelopmental Outcome: Secondary Analyses of Data from the Neonatal Research Network Hypothermia Trial: Journal of Child Neurology. ,vol. 26, pp. 322- 328 ,(2011) , 10.1177/0883073810380915
Roberto Malinow, Daniel V. Madison, Richard W. Tsien, Persistent protein kinase activity underlying long-term potentiation Nature. ,vol. 335, pp. 820- 824 ,(1988) , 10.1038/335820A0
GARY W. HESSE, TIMOTHY J. TEYLER, Reversible loss of hippocampal long term potentiation following electroconvulsive seizures Nature. ,vol. 264, pp. 562- 564 ,(1976) , 10.1038/264562A0
Sarit Avishai-Eliner, Kristen L Brunson, Curt A Sandman, Tallie Z Baram, Stressed-out, or in (utero)? Trends in Neurosciences. ,vol. 25, pp. 518- 524 ,(2002) , 10.1016/S0166-2236(02)02241-5
Henry Matthies, Thomas Behnisch, Hiroshi Kase, Hansjürgen Matthies, Klaus G. Reymann, Differential effects of protein kinase inhibitors on pre-established long-term potentiation in rat hippocampal neurons in vitro. Neuroscience Letters. ,vol. 121, pp. 259- 262 ,(1991) , 10.1016/0304-3940(91)90699-T
Larry F Abbott, JA Varela, Kamal Sen, SB Nelson, SYNAPTIC DEPRESSION AND CORTICAL GAIN CONTROL Science. ,vol. 275, pp. 220- 224 ,(1997) , 10.1126/SCIENCE.275.5297.221