Brain metabolite changes in alcoholism: an in vivo proton magnetic resonance spectroscopy (MRS) study.
作者： N.R. Jagannathan , N.G. Desai , P. Raghunathan
DOI: 10.1016/0730-725X(96)00048-3
关键词: Cerebellum 、 Magnetic resonance imaging 、 Nuclear magnetic resonance 、 Creatine 、 Choline 、 Aspartate N-acetyltransferase 、 In vivo 、 Metabolite 、 Chemistry 、 Frontal lobe
摘要: Image-guided, single voxel, localized proton magnetic resonance (MR) spectroscopy was performed to assess the brain metabolite changes in 10 (n = 10) alcoholic patients frontal lobe, cerebellum, and thalamus regions. The spectra obtained were characterized by a reduced N-acetyl-aspartate (NAA) choline (Cho) (p < .01) NAA total creatine (Cr + PCr) ratios relative age-matched 27) controls. These decreased correspond depleted concentration of levels such as Cho. Reduction is consistent with neuronal loss while reduction Cho suggests significant membrane lipids alcoholics.
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