Bioaccumulation and biotransformation of the beta-blocker propranolol in multigenerational exposure to Daphnia magna
作者： Tae-Yong Jeong , Tae-Hun Kim , Sang Don Kim
DOI: 10.1016/J.ENVPOL.2016.06.051
关键词: Animal science 、 Daphnia magna 、 Metabolite 、 Biotransformation 、 Biology 、 Bioassay 、 Environmental chemistry 、 Propranolol 、 Bioconcentration 、 Bioaccumulation 、 Daphnia
摘要: Multigenerational bioaccumulation and biotransformation activity short-term kinetics (e.g., uptake depuration) of propranolol in Daphnia magna were investigated at environmental concentration. The body burden the major metabolite, desisopropyl (DIP), quantified using LC-MS/MS end each generation after exposure for 11 generations. accumulation D. magna an concentration 0.2 μg/L was not much different between parent (F0) eleventh filial (F10) generation. However, 28 μg/L, its 1.6 times higher-up to 18.9 μg/g-in F10 relative F0. In contrast propranolol, DIP intensity gradually increased from F0 0.2 μg/L, reflecting increase detoxification load performance; no increasing trend observed 28 μg/L. factor (BAF) showed higher values with a lower longer period exposure. average BAF 21 days long-term successive generations 440.4 ± 119.7 1026.5 ± 208.6 L/kg 28 μg/L respectively. These are comparable 192 72-h It is also recommended that future studies pharmaceutical ingredients be conducted on drug-drug interaction structural characteristics prediction rate.
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