Working memory and FDG-PET dissociate early and late onset Alzheimer disease patients.

摘要: The aims of this study were to determine the influence onset Alzheimer's disease (AD) on 1) memory and cerebral glucose metabolism, 2) relationships between cognitive performance metabolism. Brain metabolism was measured by 18FDG-PET in 12 early AD patients (age 65), with comparable mean MMSE scores. Working memory, semantic episodic assessed. Cognitivo-metabolic correlations (CMC) complementary interregional performed order identify specific neurocognitive processes within each group. Both groups poorly all tasks, except digit span late group more than one both Brown-Peterson Paradigm (BPP) tasks. Temporo-parietal hypometabolism found groups, left hemisphere being affected right, especially patients, who also showed frontal hypometabolism. For BPP task, CMC principally involved areas group, cerebellum one. they cerebellar occipital regions latter. Regarding span, involvement may have reflected an effective compensatory mechanism while high supramarginal gyrus explained their failure task. In lower been due a lobe dysfunction, as suggested region, results, 3) correlations, which indicated greater disruption antero- posterior loop.