Metabolic correlates of executive dysfunction. Different patterns in mild and very mild Alzheimer's disease.

摘要: This study was designed to examine the correlations between resting-state brain glucose metabolism (CMRglc), as measured with Positron Emission Tomography and performance on executive function tasks in Alzheimer's disease (AD), while taking into account severity of cognitive deterioration. We addressed this issue 50 AD patients, classified very mild (n = 22) 28) basis an extensive neuropsychological battery. Thirteen healthy subjects were selected controls for measures. Statistical Parametric Mapping (SPM) used voxel-wise CMRglc scores tests functions: Stroop Test, Trail Making Dual Task Phonemic Fluency, correcting age global CMRglc. All analyses done separately two subgroups. The patients showed significant associations Test prefrontal regions metabolism, whereas exhibited more widely distributed cognitive-metabolic extending posterior regions. These data suggest that a large cortical network is implicated dysfunction AD, pattern varies according severity.