Prior antiplatelet therapy and outcome following intracerebral hemorrhage A systematic review

摘要: Objectives: Antiplatelet therapy (APT) promotes bleeding; therefore, APT might worsen outcome in patients with intracerebral hemorrhage (ICH). We performed a systematic review and meta-analysis to address the hypothesis that pre-ICH use is associated mortality poor functional following ICH. Methods: The Medline Embase databases were searched February 2008 using relevant key words, limited human studies English language. Cohort of consecutive ICH reporting or according identified. Of 2,873 screened, 10 judged meet inclusion criteria by consensus 2 authors. Additionally, we solicited unpublished data from all authors cohort >100 published within last years, received 15 more studies. Univariate multivariable-adjusted odds ratios (ORs) for abstracted as available pooled random effects model. Results: obtained 25 cohorts (15 unpublished) 21 (14 unpublished). Pre-ICH users had increased both univariate (OR 1.41, 95% confidence interval [CI] 1.21 1.64) 1.27, CI 1.10 1.47) analyses. By contrast, OR was no longer significant when estimates (univariate 1.29, 1.09 1.53; 1.10, 0.93 1.29). Conclusions: In studies, at time compared independently but not outcome.