Diagnostic value of serum complement C3 and C4 levels in Chinese patients with systemic lupus erythematosus.

摘要: In 2009, hypocomplementemia involving C3, C4, and total hemolytic complement (CH50) was proposed as an immunologic criterion to enhance the sensitivity of systemic lupus erythematosus (SLE) classification criteria. This study evaluated diagnostic value low serum C3 C4 levels in Chinese patients with SLE. total, 2452 were enrolled this (158 SLE 2294 other diseases). Receiver operating characteristic analysis showed that optimal cut-off for a diagnosis 0.785 g/L (sensitivity, 77.9 %; specificity, 81.5 %) 0.145 g/L 80.1 %; 83.2 %), respectively. The prevalence or level alone similar between those diseases, while simultaneously higher (73.42 %). Antinuclear antibody had high (96.64 %) negative likelihood ratio (0.04). Hypocomplementemia positive antinuclear ratio. Inclusion resulted 16.18 % increase number assigned group (from 136 158 patients). highly prevalent hematological disease (41.94 %). These results suggest has important by improving should be tested because is not suitable immunological criterion.