Evidence for involvement of receptor in tonic inhibitory control of dopaminergic transmission in rat medial frontal cortex

摘要: Abstract Bilateral infusion of dl -2-amino-5-phosphonovalerate ( -APV) (which is a competitive antagonist for N- methyl- d -aspartate (NMDA) receptor) into the medial frontal cortex conscious rats increased amount 3,4-dihydroxyphenylacetic acid (DOPAC) and DOPAC/dopamine (DA) ratio in cortical area. Moreover, intra-prefrontal injection -APV, -2-amino-7-phosphonoheptanoate 3-[(±)-2-carboxypiperazin-4-yl]-propyl-1-phosphonate are selective NMDA receptor antagonists), but not l -isomer APV γ-glutamyl-aminomethyl sulphonate (a relative non-NMDA receptors), facilitated prefrontal DA utilization NMDA-reversible manner. These findings suggest that NMDA-type excitatory amino receptors may be involved tonic inhibitory regulation dopaminergic transmission vivo.