Predictors of drug treatment response in obsessive-compulsive disorder.

摘要: Background : Although a large body of evidence indicates the efficacy pharmaco-therapy in treatment obsessive-compulsive disorder (OCD), considerable percentage these patients do not respond. Very few studies focus on factors related to response OCD. The purpose this study was investigate which clinical are drug Method We examined 53 OCD treated with either clomipramine or fluoxetine for period 6 months, dividing sample into responders and nonresponders treatment. At admission, were evaluated using semistructured interview, Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Hamilton Rating Depression, Anxiety. then compared acute-phase patient characteristics Response defined as decrease at least 40% Y-BOCS total score rating improved very Clinical Global Impressions scale within 16 weeks maintained over three consecutive evaluations. Results By sixth month treatment, 31 (58.5%) responded fluoxetine. Nonresponders had lower age onset longer duration ; addition, they showed higher frequency compulsions, washing rituals, chronic course, concomitant schizotypal personality disorder, previous hospitalizations. A worse predicted stepwise multiple regression by (1) (2) presence (3) illness length. Conclusion Our findings suggest that there distinct types respect response. They provide indirect specificity identifying responsive different modalities, may be value selection alternative treatments. (J Clin Psychiatry 1995 ;56 :368-373)