The potential application of photodynamic therapy in drug-resistant tuberculosis

摘要: Tuberculosis (TB) is an infectious bacterial disease that has historically created a high global health burden. Unfortunately, the emergence of drug-resistant TB (DR-TB), which includes multidrug-resistant (MDR-TB) and extensively (XDR-TB), greatly affected treatment TB. Anti-TB chemotherapy drugs are classified into five groups to facilitate application effective guidelines for regimen. However, limited ability treat DR-TB, therefore novel alternative DR-TB required. In this review, we focused on photodynamic therapy (PDT) as potential DR-TB. PDT widely used cancer combines photosensitizers harmless laser light produce reactive oxygen species selectively damage target cells. Initially, was originally developed pathogenic microorganisms but fell disuse because adverse reactions. Recently, antimicrobial attracting attention again infections. our previous study, suggested could be option MDR- XDR-TB in vitro. Despite studies regarding models, fast-developing bronchoscopic technologies clinician experience will soon clinical safe minimally invasive