Suppression of Ras-induced apoptosis by the Rac GTPase.

作者: Tom Joneson , Dafna Bar-Sagi

DOI: 10.1128/MCB.19.9.5892

关键词: BiologyCell biologyAnti-apoptotic Ras signalling cascadeMAPK/ERK pathwayCdc42 GTP-Binding ProteinHRASGTPase-activating proteinGTP-binding protein regulatorsSignal transductionOncogene

摘要: Ras is an essential component of signal transduction pathways that control cell proliferation, differentiation, and survival. In this study we have examined the cellular responses to high-intensity signaling. Expression increasing amounts oncogenic form human HRas, HRasV12, results in a dose-dependent induction apoptosis both primary immortalized cells. The by HRasV12 blocked activated Rac potentiated dominant interfering Rac. ability suppress Ras-induced dependent on effector pathway(s) controlled insert region linked activation NF-kappaB. apoptotic effect requires ERK JNK mitogen-activated protein kinase cascade independent p53. These demonstrate role for controlling signals are necessary survival, suggest mechanism which activity can confer growth advantage cells transformed ras oncogene.

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