作者: Tom Joneson , Dafna Bar-Sagi
关键词: Biology 、 Cell biology 、 Anti-apoptotic Ras signalling cascade 、 MAPK/ERK pathway 、 Cdc42 GTP-Binding Protein 、 HRAS 、 GTPase-activating protein 、 GTP-binding protein regulators 、 Signal transduction 、 Oncogene
摘要: Ras is an essential component of signal transduction pathways that control cell proliferation, differentiation, and survival. In this study we have examined the cellular responses to high-intensity signaling. Expression increasing amounts oncogenic form human HRas, HRasV12, results in a dose-dependent induction apoptosis both primary immortalized cells. The by HRasV12 blocked activated Rac potentiated dominant interfering Rac. ability suppress Ras-induced dependent on effector pathway(s) controlled insert region linked activation NF-kappaB. apoptotic effect requires ERK JNK mitogen-activated protein kinase cascade independent p53. These demonstrate role for controlling signals are necessary survival, suggest mechanism which activity can confer growth advantage cells transformed ras oncogene.