An updated radiosynthesis of [18F]AV1451 for tau PET imaging.
作者： Andrew V. Mossine , Allen F. Brooks , Bradford D. Henderson , Brian G. Hockley , Kirk A. Frey
DOI: 10.1186/S41181-017-0027-7
关键词: Nuclear medicine 、 Clinical imaging 、 Fully automated 、 Radiochemistry 、 Radiosynthesis 、 Automated radiosynthesis 、 Chemistry
摘要: [18F]AV1451 is a commonly used radiotracer for imaging tau deposits in Alzheimer’s disease (AD) and related non-AD tauopathies. Existing radiosyntheses of require complex purifications to provide doses suitable use clinical studies. To address this issue, we have modified the synthesis only 0.5 mg precursor, optimized Boc-deprotection step developed simplified method HPLC purification radiotracer. An using TRACERLab FXFN module led high radiochemical yield (202 ± 57 mCi per synthesis) with excellent purity (98 ± 1%) good specific activity (2521 ± 623 Ci/mmol). updated operationally simple has been that fully automated prepares PET
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