Interleukin-1 and the response to injury.

摘要: Traumatic injury is the leading cause of morbidity and mortality in Americans less than 45 years old [26]. People surviving initial insult undergo metabolic, hemodynamic immunologic changes which contribute to both early late complications. Though necessary for normal response wound healing, pathologic alterations IL-1 synthesis, degradation, binding receptors on a local systemic level could lead these changes. Manipulation mediated effects might be therapeutic utility management trauma future.