Therapeutic effect of continuous exercise training program on serum creatinine concentration in men with hypertension: a randomized controlled trial.

作者: L Sikiru , GC Okoye

DOI: 10.4314/GMJ.V48I3.3

关键词: Waist–hip ratioEssential hypertensionBlood pressureTherapeutic effectRandomized controlled trialCreatinineCardiologyInternal medicineBody mass indexEndocrinologyContinuous trainingMedicine

摘要: Background : Creatinine (Cr) has been implicated as an independent predictor of hypertension and exercise reported adjunct therapy for hypertension. The purpose the present study was to  investigate effect continuous training programme on blood pressure serum creatinine concentration in black African subjects with  Methods Three hundred fifty seven male patients with mild moderate (systolic [SBP] between 140-180 & diastolic [DBP] 90-109 mmHg) essential were age matched randomly grouped into control groups. group involved 8 weeks (60-79% HR reserve) 45minutes to 60 minutes, 3 times per week, while remain sedentary. SBP, DBP, VO2max, Cr, body mass index (BMI), waist hip ratio (WHR) percent (%) fat. Analysis covariance (ANCOVA) Pearson correlation tests used data analysis. Results Findings revealed significant decreased effects BMI, WHR, % fat increase VO2max at p< 0.05. Serum Cr is significantly negatively correlated SBP (-.335), DBP (.194), BMI (.268), WHR (-.258) (-.190) p<0.05. Conclusion demonstrated a rationale bases therapeutic role intensity multitherapy down regulation pressure, size Key words Hypertension; Blood pressure; Creatinine; size; fat; Africa.

参考文章(27)
A A Gaeini, N Rahnama, M R Hamedinia, Oxidative stress responses in physical education students during 8 weeks aerobic training. Journal of Sports Medicine and Physical Fitness. ,vol. 47, pp. 119- 123 ,(2007)
William D. McArdle, Frank I. Katch, Victor L. Katch, Exercise Physiology: Energy, Nutrition, and Human Performance ,(2006)
Bertram G. Katzung, Basic And Clinical Pharmacology ,(1982)
P S Bachorik, Collection of blood samples for lipoprotein analysis. Clinical Chemistry. ,vol. 28, pp. 1375- 1378 ,(1982) , 10.1093/CLINCHEM/28.6.1375
Garth A. Nicholson, James G. McLeod, Graeme Morgan, Matthew Meerkin, Judith Cowan, Allan Bretag, Daryl Graham, Geoffrey Hill, Evelyn Robertson, Leslie Sheffield, Variable distributions of serum creatine kinase reference values Journal of the Neurological Sciences. ,vol. 71, pp. 233- 245 ,(1985) , 10.1016/0022-510X(85)90062-0
M.L. Kohut, D.A. McCann, D.W. Russell, D.N. Konopka, J.E. Cunnick, W.D. Franke, M.C. Castillo, A.E. Reighard, E. Vanderah, Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of β-blockers, BMI, and psychosocial factors in older adults Brain Behavior and Immunity. ,vol. 20, pp. 201- 209 ,(2006) , 10.1016/J.BBI.2005.12.002
Nicola Longo, Orly Ardon, Rena Vanzo, Elizabeth Schwartz, Marzia Pasquali, Disorders of creatine transport and metabolism American Journal of Medical Genetics Part C: Seminars in Medical Genetics. ,vol. 157, pp. 72- 78 ,(2011) , 10.1002/AJMG.C.30292
R TOWNSEND, C MCFADDEN, V FORD, J CADEE, A randomized, double-blind, placebo-controlled trial of casein protein hydrolysate (C12 peptide) in human essential hypertension American Journal of Hypertension. ,vol. 17, pp. 1056- 1058 ,(2004) , 10.1016/J.AMJHYPER.2004.06.018
Josef Coresh, G. Laura Wei, Geraldine McQuillan, Fredrick L Brancati, Andrew S. Levey, Camille Jones, Michael J. Klag, Prevalence of High Blood Pressure and Elevated Serum Creatinine Level in the United States Archives of Internal Medicine. ,vol. 161, pp. 1207- 1216 ,(2001) , 10.1001/ARCHINTE.161.9.1207
Catherine F. Terry, Valerie Loukaci, Fiona R. Green, Cooperative Influence of Genetic Polymorphisms on Interleukin 6 Transcriptional Regulation Journal of Biological Chemistry. ,vol. 275, pp. 18138- 18144 ,(2000) , 10.1074/JBC.M000379200