Allelotyping of human prostatic adenocarcinoma

作者: Kazuto Kunimi , Ulf S.R. Bergerheim , Inga-Lisa Larsson , Peter Ekman , V.Peter Collins

DOI: 10.1016/0888-7543(91)90059-N

关键词: Genetic markerCentromereGeneticsBiologyChromosome 16ChromosomeMolecular biologyRestriction fragment length polymorphismChromosome 18MutationAllele

摘要: Allelotyping (using at least one probe detecting a restriction fragment length polymorphism on each chromosomal arm, with the exception of short arms acrocentric chromosomes), showed loss genetic information in 11 18 prostate adenocarcinoma specimens analyzed (61%). Frequent allelic deletions were detected long arm chromosome 16 (6 10 informative cases, 60%), 8 (3 6 50%), and and/or cases (10p), 55% 4 13 (10q), 30%, respectively). No losses alleles any case unless chromosomes 8, 10, or also deletions. The high frequency 7 43%). Allelic following lower frequencies: 2, 3, 7, 12, 13, 17, 22, XY. Tumors more than had higher histological malignancy grade. from patients advanced disease all

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