miR-222 attenuates cisplatin-induced cell death by targeting the PPP2R2A/Akt/mTOR Axis in bladder cancer cells.

摘要: Increased miR-222 levels are associated with a poor prognosis in patients bladder cancer. However, the role of remains unclear. In present study, we found that enhanced proliferation both T24 and 5637 cancer cell lines. Overexpression attenuated cisplatin-induced death cells. activated Akt/mTOR pathway inhibited autophagy cells by directly targeting protein phosphatase 2A subunit B (PPP2R2A). Blocking activation Akt LY294002 or mTOR rapamycin significantly prevented miR-222-induced restored sensitivity to cisplatin. These findings demonstrate modulates PPP2R2A/Akt/mTOR axis thus plays critical regulating chemotherapeutic drug resistance. Therefore, may be novel therapeutic target for