Clinical predictor and circulating microRNA profile expression in patients with early onset post-stroke depression.

摘要: Abstract Objective We aim to explore the clinical factors and blood biomarker for predicting early-onset post-stroke depression (PSD). Methods 251 acute ischemic stroke patients were divided into PSD group non-PSD by Hamilton scale in 2 weeks after stroke. The data, severity, etiology location of recorded. analysis inflammatory mediator, glycose lipid metabolism was performed on day admission. association between early onset studied logistic regression analysis. In addition, differentially expressed miRNAs plasma two groups screened gene chip bio-information further investigated GO KEEG Results Among patients, 45 (17.93%) diagnosed as PSD. NIHSS score (>3) carotid stenosis independent relative with (OR 3.479 2.617, p =0.000 0.009, respectively). Moreover, lower LDL trended toward minor subgroup ( =0.084). MiRNA profile demonstrated 25 differential circulating FC≥2 P ≤0.05 groups. target genes these enriched pathways cancer MAPK signaling. Limitations sample study small. results should be confirmed large cohort patients. Conclusions Early more likely severe neurological deficits artery stenosis, also note possible Blood may served a potential diagnosis.