The human pharmacokinetics of odanacatib, a novel cathepsin K inhibitor, predicted by interspecies scaling: a retrospective analysis
作者： Ravi Kanth Bhamidipati , Sandip Gurav , Anitha Police , Zainuddin Mohd , Sriram Rajagopal
关键词: Cathepsin K 、 Pharmacology 、 Volume of distribution 、 Interspecies scaling 、 Allometry 、 Retrospective analysis 、 Bile flow 、 Biology 、 Odanacatib 、 Pharmacokinetics
摘要: Aim: The objective of this exercise was to explore the utility allometry for predicting intravenous and oral pharmacokinetics odanacatib. Methods: relation between pharmacokinetic parameters (viz., volume distribution clearance [CL]) body weight examined across four species, using double logarithmic plots predict CL simple biliary correction factors. Results: Best concurrence plasma exposure odanacatib in humans obtained with values predicted from value CF2 (bile flow rate/body weight) factor. Conclusion: outcome indicates that interspecies scaling suitable factors could be used human
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