Simultaneous Control of Hyperglycemia and Oxidative Stress Normalizes Endothelial Function in Type 1 Diabetes
作者： A. Ceriello , S. Kumar , L. Piconi , K. Esposito , D. Giugliano
DOI: 10.2337/DC06-2048
关键词: Internal medicine 、 Type 1 diabetes 、 Oxidative stress 、 Endothelium 、 Endothelial dysfunction 、 Insulin 、 Vitamin 、 Medicine 、 Endocrinology 、 Diabetes mellitus 、 Vitamin C
摘要: OBJECTIVE—Previous studies have shown that in type 1 diabetes endothelial dysfunction persists even when glycemia is normalized. Moreover, oxidative stress has recently been demonstrated to be the mediator of hyperglycemia-induced dysfunction. RESEARCH DESIGN AND METHODS—Thirty-six diabetic patients and 12 control subjects were enrolled. The divided into three groups. first group was treated for 24 h with insulin, achieving a near-normalization glycemia. After this treatment, vitamin C added remaining h. second C. insulin started, achievement third both RESULTS—Neither normalization nor treatment alone able normalize or stress. However, combination normalized decreased normal levels. CONCLUSIONS—This study suggests long-lasting hyperglycemia induces permanent alterations cells, which may contribute by increased
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