Use of moist oral snuff (snus) and pancreatic cancer: Pooled analysis of nine prospective observational studies.

摘要: While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco less well understood. We used pooled individual data from Swedish Collaboration on Health Effects Snus Use to assess association between snus use and cancer. A total 424,152 male participants nine cohort studies were followed up cancer through linkage health registers. shared frailty models with random effects at study level, estimate hazard ratios (HRs) 95% confidence intervals (CIs) adjusted confounding factors. During 9,276,054 person-years observation, 1,447 men developed Compared never-snus use, current was not associated (HR 0.96, CI 0.83-1.11) after adjustment smoking. does appear be implicated in development men. Tobacco smoke constituents other than nicotine or its metabolites may account relationship