Role of Bcl-2, Bax, and Bak in spontaneous apoptosis and proliferation in neuroendocrine lung tumors: immunohistochemical study.
作者： M. A. Pal’tsev , S. A. Demura , E. A. Kogan , G. Jaques , B. Zende
DOI: 10.1007/BF02682109
关键词: Lung 、 Spontaneous apoptosis 、 Phosphorylation 、 Immunohistochemistry 、 Apoptosis 、 Small Cell Lung Carcinoma 、 Nucleus 、 Pathology 、 Carcinoma 、 Biology
摘要: Fifty-six primary neuroendocrine lung tumors were examined morphologically and histologically their apoptosis level was determined. Malignant carcinomas characterized by increased apoptotic index enhanced expression ofBcl-2, Bak, p53, andKi-67 compared to typical carcinoid. However, in these not completed. Proteins of theBcl family play an important role the regulation spontaneous tumors.Bcl-2 accumulating nucleus is a morphological analogue phosphorylated inactive form this protein, which does inhibit apoptosis. Expression ofBcl-2 andBax decreases small-cell carcinoma (SCLC) with metastases indicating attenuation development metastatic clones resistant induces.
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