Vaccination with a Nogo-A-derived peptide after incomplete spinal-cord injury promotes recovery via a T-cell-mediated neuroprotective response: Comparison with other myelin antigens

摘要: The myelin-associated protein Nogo-A has received more research attention than any other inhibitor of axonal regeneration in the injured central nervous system (CNS). Circumvention its inhibitory effect, by using antibodies specific to Nogo-A, been shown promote regrowth. Studies our laboratory have demonstrated that active or passive immunization CNS-injured rats mice with peptides induces a T-cell-mediated protective autoimmune response, which promotes recovery reducing posttraumatic degeneration. Here, we show neuronal degeneration after incomplete spinal-cord contusion was substantially reduced, and hence significantly promoted, p472, peptide derived from Nogo-A. observed effect seemed be mediated T cells could reproduced transfer cell line directed against peptide. Thus, it seems injury, variety peptides, including those can used evoke cell-mediated response recovery. choice peptide(s) for clinical treatment injuries should based on safety considerations; particular, likelihood chosen will not cause an disease interfere essential functions this proteins. From therapeutic point view, fact cellular agents are rather is advantage, as production commences within time window required whereas antibody takes longer.