Comparison of acetate inhibition on growth of host and recombinantE. coli K12 strains

作者: Boon Tong Koh , Utaka Nakashimada , Marco Pfeiffer , Miranda G. S. Yap

DOI: 10.1007/BF01027012

关键词: Chemically defined mediumBiochemistryRecombinant DNABacteriaEscherichia coliHost (biology)EnterobacteriaceaeBiologyMicrobiologyBiotechnologyGeneral Medicine

摘要: We investigated the extent of acetate inhibition on growth rate different host and recombinantE. coli K12 strains, cultivated in defined complex media. A mathematical model was proposed to describe this inhibition. Our results show that is more significant for recombinant cells than cells, cultured medium medium.

参考文章(8)
Norio Shimizu, Shinichi Fukuzono, Kiyoshi Fujimori, Nabuko Nishimura, Yoji Odawara, Fed-batch cultures of recombinant Escherichia coli with inhibitory substance concentration monitoring Journal of Fermentation Technology. ,vol. 66, pp. 187- 191 ,(1988) , 10.1016/0385-6380(88)90046-5
T. D. K. BROWN, M. C. JONES-MORTIMER, H. L. KORNBERG, The enzymic interconversion of acetate and acetyl-coenzyme A in Escherichia coli. Microbiology. ,vol. 102, pp. 327- 336 ,(1977) , 10.1099/00221287-102-2-327
Jae Gu Pan, Joon Shick Rhee, Jean M. Lebeault, Physiological constraints in increasing biomass concentration of Escherichia coli B in fed-batch culture Biotechnology Letters. ,vol. 9, pp. 89- 94 ,(1987) , 10.1007/BF01032744
Keehyun Han, Henry C. Lim, Juan Hong, Acetic acid formation in escherichia coli fermentation Biotechnology and Bioengineering. ,vol. 39, pp. 663- 671 ,(1992) , 10.1002/BIT.260390611
Konstantin Konstantinov, Michimasa Kishimoto, Tatsuji Seki, Toshiomi Yoshida, A balanced DO-stat and its application to the control of acetic acid excretion by recombinant Escherichia coli. Biotechnology and Bioengineering. ,vol. 36, pp. 750- 758 ,(1990) , 10.1002/BIT.260360714