Comparative efficacy and safety of cefprozil versus penicillin, cefaclor and erythromycin in the treatment of streptococcal pharyngitis and tonsillitis

摘要: Cefprozil is a new oral cephalosporin with an enhanced in vitro spectrum of activity that includes group A beta-hemolytic streptococci (GABHS). Four multicenter randomized clinical trials were conducted to compare the efficacy and safety cefprozil administered once or twice day for treatment mild moderate GABHS tonsillitis pharyngitis. total 1597 patients enrolled trials. Patient demographics severity infection similar all groups. In Study 1, at 20 mg/kg daily was clinically, 68 76 (89%) bacteriologically, 66 74 superior penicillin -51 69 (74%) 46 (67%)--administered three times two 12 years age. 2, 13 age older, had (93% vs. 90%) bacteriological (95% 94%) response rates as cefaclor day. 3 demonstrated given day, satisfactory being 164 175 (94%) 146 165 (88%) penicillin. 4, identical bacteriologic responses (95%) observed erythromycin ethylsuccinate four children over There no significant differences incidence drug-related adverse events, which, when reported, transient.(ABSTRACT TRUNCATED AT 250 WORDS)