Ewing sarcoma: a chronicle of molecular pathogenesis
作者： Sang Kyum Kim , Yong-Koo Park
DOI: 10.1016/J.HUMPATH.2016.05.008
关键词: Malignancy 、 Gene 、 TAF15 、 Pathology 、 Chromosomal translocation 、 Biology 、 Mesenchymal stem cell 、 Round cell 、 Sarcoma 、 Molecular pathogenesis
摘要: Sarcomas have traditionally been classified according to their chromosomal alterations regardless of whether they accompany simple or complex genetic changes. Ewing sarcoma, a classic small round cell bone tumor, is well-known mesenchymal malignancy that results from sarcoma-specific alterations. The are translocations between genes the TET/FET family (TLS/FUS, EWSR1, and TAF15) E26 transformation-specific (ETS) family. In this review, we intend summarize chronicle molecular findings sarcoma including recent advances explain resultant pathogenesis.
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