Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer

作者: G. Sanchez , D. Bittencourt , K. Laud , J. Barbier , O. Delattre

DOI: 10.1073/PNAS.0710748105

关键词: Transcription (biology)FLI1Regulation of gene expressionBiologyCyclin D1Alternative splicingTranscription factorGene isoformTranscriptional regulationMolecular biology

摘要: … splice variants in panels of EwSa and breast cancer (BrCa) cell lines. BrCa cells were good models for our purpose because they also express high levels of cyclin D1 (14). Absolute …

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