Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption.

摘要: The process of bone remodeling is the result regulated balance between cell populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and osteocyte, mechanosensory type. Osteoclasts derived from hematopoietic stem lineage are principal cells involved in resorption. In osteolytic diseases such as rheumatoid arthritis, periodontitis, osteoporosis, lost changes favor Therefore, it vital to elucidate mechanisms osteoclast formation It has been reported that osteocytes express Receptor activator nuclear factor κΒ ligand (RANKL), an essential for formation. RANKL secreted by most important physiologically supported developing skeleton pathological resorption experimental periodontal loss. TNF-α directly enhances expression promotes Moreover, sclerostin osteocytes, which also increases These findings suggest osteocyte-related cytokines act enhance this review, we outline recent knowledge concerning resorption-related discuss osteocyte master regulator effector