Choroidal metastases fundus autofluorescence imaging: correlation to clinical, OCT, and fluorescein angiographic findings.

作者: Sribhargava Natesh , Kimberly J. Chin , Paul T. Finger

DOI: 10.3928/15428877-20100426-03

关键词: Fluorescein angiographyRetinal detachmentRetinaMelanomaOphthalmoscopyRetinalOptical coherence tomographyOphthalmologyHyperpigmentationMedicine

摘要: Background and objective To correlate fundus autofluorescence (FAF) characteristics of metastatic choroidal tumors with optical coherence tomography/scanning laser ophthalmoscope (OCT/SLO). Patients methods A retrospective review 10 metastases in 9 patients. Results All were amelanotic, although 8 exhibited surface pigmentation. FAF imaging revealed hyperautofluorescence areas focal pigmentation subretinal fluid hypoautofluorescent margins (n = 5) corresponding to OCT evidence retinal pigment epithelial (RPE) thickening fluid. Loss RPE was hypoautofluorescent. images changed tumor growth. best elevation the retina, folds, detachment. Conclusion defined margins. correlated hyperpigmentation, fluid, advancing edges. better demonstrated intraretinal findings (atrophy, increased lost RPE). This study shows that reveal unique metastasis.

参考文章(8)
T. Michael Redmond, Martin L. Katz, Effect of Rpe65 knockout on accumulation of lipofuscin fluorophores in the retinal pigment epithelium. Investigative Ophthalmology & Visual Science. ,vol. 42, pp. 3023- 3030 ,(2001)
Tomoka Ishida, Kyoko Ohno-Matsui, Yuh Kaneko, Hideaki Tobita, Kengo Hayashi, Noriaki Shimada, Manabu Mochizuki, Autofluorescence of metastatic choroidal tumor International Ophthalmology. ,vol. 29, pp. 309- 313 ,(2009) , 10.1007/S10792-008-9234-2
STEFFEN SCHMITZ-VALCKENBERG, FRANK G. HOLZ, ALAN C. BIRD, RICHARD F. SPAIDE, Fundus autofluorescence imaging: review and perspectives. Retina-the Journal of Retinal and Vitreous Diseases. ,vol. 28, pp. 385- 409 ,(2008) , 10.1097/IAE.0B013E318164A907
J. Fernando Arevalo, Carlos F. Fernandez, Reinaldo A. Garcia, Optical coherence tomography characteristics of choroidal metastasis. Ophthalmology. ,vol. 112, pp. 1612- 1619 ,(2005) , 10.1016/J.OPHTHA.2005.03.030
A von Ruckmann, F W Fitzke, A C Bird, Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. British Journal of Ophthalmology. ,vol. 79, pp. 407- 412 ,(1995) , 10.1136/BJO.79.5.407
Ingolf H.L. Wallow, Mark O.M. Ts'o, Proliferation of the Retinal Pigment Epithelium Over Malignant Choroidal Tumors: A Light and Electron Microscopic Study American Journal of Ophthalmology. ,vol. 73, pp. 914- 926 ,(1972) , 10.1016/0002-9394(72)90461-8
Madhavi Kurli, Shantan Reddy, Lawrence B. Tena, Anna C. Pavlick, Paul T. Finger, Whole body positron emission tomography/computed tomography staging of metastatic choroidal melanoma. American Journal of Ophthalmology. ,vol. 140, pp. 193- 199 ,(2005) , 10.1016/J.AJO.2005.02.051
LUCIENNE C. COLLET, JOSE S. PULIDO, KAAN GÜNDÜZ, TERESA DIAGO, COLIN MCCANNEL, CHRISTOPHER BLODI, THOMAS LINK, Fundus autofluorescence in choroidal metastatic lesions: a pilot study. Retina-the Journal of Retinal and Vitreous Diseases. ,vol. 28, pp. 1251- 1256 ,(2008) , 10.1097/IAE.0B013E318188C7D0