Impaired immunologic reactivity and recurrence following cancer surgery

摘要: One hundred patients were tested for their ability to react 7 commonly encountered skin test antigens and develop delayed cutaneous hypersensitivity 2, 4-dinitrochlorobenzene (DNCB). Following sensitization, more than 95% of normal patients, but only 60% with potentially resectable neoplasms, exhibited DNCB. A correlation is suggested between the inability DNCB incidence either inoperability, local recurrence, or distant metastases within 6 months post-operatively. Ninety-three percent (27/29) who failed inoperable developed early whereas 92% (50/54) reacted free disease months; many these nonreactive all common antigens. These studies suggest that there a significant cell mediated immunologic reactivity as measured by course malignant following definitive cancer surgery.