Serum TNF alpha levels: a prognostic marker for assessment of severity of malaria.

摘要: Complicated Plasmodium falciparum infection is associated with a 6.4% mortality rate in India, yet its prognostication incompletely understood. The conventional prognostic markers of malaria include clinical, haematological and biochemical parameters. However these factors are non-specific. Hence there need an accurate inexpensive objective marker for prognosticating outcomes. Angiopoietins, angiogenic factors, eotaxins, adhesion molecules inflammatory cytokines have been studied this common disease. Determination the first four technically difficult requires high level expertise equipment. Intermediary most promising role. This study was conducted aim to evaluate serum TNF-α patients P. carry out statistical analysis levels parasite index, age, severity anaemia, hypoglycaemia, hepatic renal dysfunction. In our average TNF alpha 91healthy controls 46.42 pg/ml whereas that mild 100.45 pg/ml, severe - 278.63 cerebral it 532.6 pg/ml. mean significantly different compared healthy (p < 0.02). difference higher altered liver functions, hyperparasitemia, leucocytosis, hepatosplenomegaly hypoglycaemia. did not correlate well haemolysis function. raised can predict likelihood oncoming function leucocytosis but grades malaria. duration stay hospital change index between 5(th) day 1(st) admission used clinical outcome study. showed (p= 0.001) longer hospital. cytokine having disorientation /cognitive disorder /coma ARDS 0.001, 0.0023 respectively). concluded if done at time on 3 indicate disease complications.