Duodenal prostaglandin synthesis and acid load in health and in duodenal ulcer disease

摘要: We sought to test the hypothesis that duodenal ulcer disease results from an imbalance between acid load, injurious force, and mucosal prostaglandin generation, a protective factor. Ten patients with 8 healthy controls were studied. The load after amino soup was quantified by double-marker technique. Mucosal biopsy specimens taken endoscopically bulb before meal. Prostaglandin synthesis activity measured incubating homogenates in excess [14C]arachidonic acid. Although mean higher ulcer, ranges overlapped. Neither qualitative nor quantitative profile of activities differed significantly groups. activities, however, tended increase post cibum controls, but change little or decrease ulcer. Only comparing responses meal both parameters together (duodenal activities) there complete nearly separation controls. Greatest discrimination observed prostacyclin (6-keto-PGF1 alpha). conclude health, generation duodenum is induced relation load; this may be physiologic example adaptive cytoprotection. In defect such mechanism.