Signal transduction growth factors: the effective governance of transcription and cellular adhesion in cancer invasion.
作者： Marina Di Domenico , Antonio Giordano
DOI: 10.18632/ONCOTARGET.16300
关键词: Biology 、 Nerve growth factor 、 Cadherin 、 Molecular medicine 、 Cancer research 、 Cell adhesion 、 Phosphorylation 、 Signal transduction 、 Transcription (biology) 、 Epidermal growth factor
摘要: // Marina Di Domenico 1,2,4 and Antonio Giordano 3,4 1 Department of Biochemistry, Biophysics General Pathology, University Campania “Luigi Vanvitelli”, Naples, Italy 2 IRCCS Institute Women’s Health Malzoni Clinic, Avellino, 3 Medicine, Surgery Neuroscience, Siena, 4 Sbarro for Cancer Research Molecular Center Biotechnology, Temple University, Philadelphia, PA, USA Correspondence to: Domenico, email: Keywords : cancer invasion, e-cadherin, phosphorylation, EGFR TGFβ, KGF Received December 01, 2016 Accepted March 2017 Published 16, Abstract Giulio Bizzozero classified the tissues concerning their capacity to self-renew during adult life in labile, stable permanent tissues. In 1940 Viktor Hamburger Rita Levi Montalcini exposed possibility induce growth cells thanks a specific ligand Nerve Growth Factor (NGF). Stanley Cohen purified protein Epidermal (EGF), able epidermis proliferation elicit precocious eye disclosure teeth eruption, establishing “inverse” relationships between differentiation. These two biological effects induced by EGF were according signaling is involved large array cellular functions such as proliferation, survival, adhesion, migration This review focused on key role factors downstream effectors physiological pathological phenomena, authors highlight governance EMT invasion.
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